FIELD: biotechnology.
SUBSTANCE: invention relates to various variants of the IgG2 constant region, with reduced heterogeneity of the IgG2 hinge region compared to the heterogeneity of the wild-type IgG2 constant region, as well as to protein molecules containing it.
EFFECT: proposed molecules have improved pharmacokinetic properties.
11 cl, 24 dwg, 5 tbl, 12 ex
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