CATIONIC BRANCHED PEPTIDE FOR RESPIRATORY VIRUS INHIBITION Russian patent published in 2024 - IPC A61K38/10 A61P31/16 A61P11/06 

Abstract RU 2810986 C2

FIELD: medicine.

SUBSTANCE: following is proposed: a method of intranasal administration of R4K2 KQLLPIVNKQSC peptide for the treatment of a respiratory viral infection caused by respiratory syncytial virus or influenza virus, where R is arginine; K is lysine; Q is glutamine, L is leucine, P is proline, I is isoleucine, V is valine, N is asparagine, S is serine, C is cysteine.

EFFECT: cationic branched R4K2 KQLLPIVNKQSC peptide blocks the entry of the virus into the cell both by binding to the cellular receptor nucleolin and by binding to ligands (F protein) on the surface of RSV.

1 cl, 13 dwg, 6 tbl, 8 ex

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RU 2 810 986 C2

Authors

Khaitov Musa Rakhimovich

Shilovskij Igor Petrovich

Smirnov Valerij Valerevich

Kozhikhova Kseniya Vadimovna

Andreev Sergej Mikhajlovich

Yumashev Kirill Valerevich

Vishnyakova Lyudmila Ivanovna

Shatilov Artem Andreevich

Shatilova Anastasiya Vitalevna

Dates

2024-01-09Published

2022-04-28Filed