FLUORINATED PYRAZOLYL THIOSEMICARBAZONES WITH ANTITUMOR ACTIVITY Russian patent published in 2022 - IPC C07D231/18 A61K31/415 A61P35/00 

Abstract RU 2772460 C1

FIELD: pharmaceutics.

SUBSTANCE: invention relates to compounds of the pyrazolyl thiosemicarbazones class, namely 2-{1-[3-(trifluoromethyl)-1H-pyrazol-5-yl]ethylidene}-N-arylhydrazine carbotioamides of general formula I.

EFFECT: pyrazolyl semicarbazone compounds with antitumor activity against the culture of lung carcinoma and epidermoid carcinoma of the human larynx.

1 cl, 1 tbl, 5 ex

Similar patents RU2772460C1

Title Year Author Number
6-TRIFLUORO(TRICHLORO)METHYL-SUBSTITUTED SPIRO[CHROMENO[3,4-a]PYRROLIZIDINE-11,3'-INDOLINE]-2'-ONES SHOWING ANTITUMOR ACTIVITY, AND THEIR PRODUCTION METHOD 2020
  • Korotaev Vladislav Iurevich
  • Barkov Aleksei Iurevich
  • Kutiashev Igor Borisovich
  • Ulitko Mariia Valerevna
  • Zimnitskii Nikolai Sergeevich
  • Sosnovskikh Viacheslav Iakovlevich
RU2775605C2
METHOD OF PRODUCING 1-[5-(PERFLUOROALKYL)-1N-PYRAZOL-3-YL]ETHANONES 2020
  • Kudyakova Yuliya Sergeevna
  • Edilova Yuliya Olegovna
  • Onoprienko Aleksandra Yanovna
  • Burgart Yanina Valerevna
  • Saloutin Viktor Ivanovich
  • Bazhin Denis Nazarovich
RU2741549C1
METHYL-3-ARYL-3A-NITRO-4-(TRIFLUOROMETHYL)-1,2,3,3A,4,9B-HEXAHYDROCHROMENO[3,4-C]PYRROLE-1-CARBOXYLATES, HAVING CYTOTOXIC ACTIVITY ON CELL LINE HUMAN CERVICAL CARCINOMA HELA, AND METHOD FOR PRODUCTION THEREOF 2023
  • Korotaev Vladislav Iurevich
  • Barkov Aleksei Iurevich
  • Kochnev Ivan Alekseevich
  • Ulitko Mariia Valerevna
  • Zimnitskii Nikolai Sergeevich
  • Sosnovskikh Viacheslav Iakovlevich
RU2818191C1
SPIRO CONDENSED DERIVATIVES OF 2,3-DIHYDROINDOLE, THEIR USE IN OPHTHALMOLOGY 2017
  • Zefirov Nikolaj Serafimovich
  • Proskurnina Marina Valentinovna
  • Lozinskaya Natalya Aleksandrovna
  • Sosonyuk Sergej Evgenevich
  • Volkova Mariya Sergeevna
  • Zaryanova Ekaterina Vitalevna
  • Roziev Rakhimdzhan Akhmetdzhanovich
  • Bondarenko Ekaterina Valerevna
RU2712039C2
3-TRIAZENONE INDOLES POSSESSING MYCOBACTERIUM ACTIVITY 2016
  • Apt Aleksandr Solomonovich
  • Velezheva Valeriya Sergeevna
  • Nikonenko Boris Vladimirovich
  • Kornienko Albert Grigorevich
  • Majorov Konstantin Borisovich
  • Ivanov Pavel Yurevich
  • Kondrateva Tatyana Konstantinovna
  • Korotetskaya Marina Valerevna
  • Salina Elena Gennadevna
RU2724334C1
FLUORINATED 1,3-DIKETONES WITH HYDRASONO-BENZO SUBSTITUTE AS ANTI-FRICTION ADDITIVES TO GREASES 2022
  • Gorbunova Tatiana Ivanovna
  • Edilova Yuliya Olegovna
  • Kudyakova Yuliya Sergeevna
  • Saloutin Viktor Ivanovich
  • Bazhin Denis Nazarovich
RU2796025C1
METHOD FOR INHIBITING TUMOR CELLS WITH NEW DERIVATIVES OF 3-TRIFLUOROMETHYLQUINOXALINE 1,4-DIOXIDE 2020
  • Shchekotikhin Andrej Egorovich
  • Buravchenko Galina Igorevna
  • Shcherbakov Aleksandr Mikhajlovich
RU2746395C1
3-ARYL-4-(TRIFLUOROMETHYL)-4H-SPIRO[CHROMENO[3,4-C]PYRROLIDINE-1,3'-OXINDOLES] HAVING HIGH CYTOTOXIC ACTIVITY AGAINST HUMAN UTERINE NECK CARCINOMA HeLa CELLS, AND THE METHOD FOR THEIR PREPARATION 2021
  • Korotaev Vladislav Iurevich
  • Barkov Aleksei Iurevich
  • Kutiashev Igor Borisovich
  • Ulitko Mariia Valerevna
  • Zimnitskii Nikolai Sergeevich
  • Sosnovskikh Viacheslav Iakovlevich
RU2774705C1
INDOLINONE DERIVATIVES HAVING MELATONIN RECEPTOR LIGAND PROPERTIES AND USE THEREOF 2017
  • Volkova Mariya Sergeevna
  • Zaryanova Ekaterina Vitalevna
  • Roziev Rakhimdzhan Akhmetdzhanovich
  • Bondarenko Ekaterina Valerevna
  • Zefirov Nikolaj Serafimovich
  • Proskurnina Marina Valentinovna
  • Lozinskaya Natalya Aleksandrovna
  • Sosonyuk Sergej Evgenevich
RU2712036C2
N-ACYL-N'-(PYRIDIN-2-YL)CARBAMIDES AND THEIR ANALOGUES EXHIBITING ANTICANCER AND ANTIPROLIFERATIVE ACTIVITY 2014
  • Kaufman Majkl D.
  • Kolduell Timoti Malkolm
  • Flinn Deniel L.
  • Patt Uilyam S.
  • Samarakoon Tivanka
  • Vogeti Lakshminarayana
  • Jejts Karen M.
RU2769607C2

RU 2 772 460 C1

Authors

Kudyakova Yuliya Sergeevna

Edilova Yuliya Olegovna

Shtro Anna Andreevna

Galochkina Anastasiya Valerevna

Nikolaeva Yuliya Vladimirovna

Burgart Yanina Valerevna

Saloutin Viktor Ivanovich

Bazhin Denis Nazarovich

Dates

2022-05-20Published

2021-08-10Filed