TEST SYSTEM AND METHOD FOR DETECTING SESN1 GENE DELETIONS Russian patent published in 2022 - IPC C12Q1/68 G01N33/50 C12Q1/6886 

FIELD: medicine.

SUBSTANCE: invention relates to the field of medicine, oncology, in particular hematology. A pool of oligonucleotide primers has been proposed for the specific amplification of six microsatellite loci of SESN1 gene introns, which can be used in a test system for determining SESN1 gene deletions by multiplex polymerase chain reaction (PCR), as well as in a method for identifying patients with an unfavorable course of follicular lymphoma by the presence of significant SESN1 gene deletions using the aforementioned test system.

EFFECT: presence of deletions of the SESN1 gene in the case of heterozygous inheritance based on the absence of peaks of one of the alleles or a decrease in the intensity of its fluorescence relative to the peak of the second allele of the corresponding microsatellite locus in tumor tissue when compared with the control sample makes it possible to identify a group of patients with an unfavorable course of follicular lymphoma.

5 cl, 2 dwg, 1 tbl, 2 ex