FIELD: medical biotechnology.
SUBSTANCE: invention relates to oncology, in particular to cancers characterized by microsatellite instability (MSI) and/or mismatch repair deficiency (MMR−). A diagnostic panel of markers for the analysis of MSI loci is presented along with a method and kit for using the said panel in the detection of cancers characterized by microsatellite instability (MSI) and/or mismatch repair deficiency (MMR−). A cell derived from the HTC116 c1.110268743 cell line is presented for use as a control biological sample.
EFFECT: invention makes it possible to detect MSI in CRC even at its early stages in cancer tissue samples such as ovarian cancer, endometrial cancer and gastric cancer, the invention also can be used for prognostic and long-term studies in the context of immunotherapy.
23 cl, 7 dwg
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