FIELD: medicine.
SUBSTANCE: invention relates to a compound of the general formula I or its stereoisomer, in which R1 is selected from hydrogen and unsubstituted C1-C6 alkyl; R2 and R3, each independently, is selected from hydrogen and -C(=O)Ra; R4 is selected from hydrogen and -C(=O)Ra; Ra is unsubstituted C1-C6 alkyl. The invention also relates to a method for the production of a compound of the formula I by cultivation of PHM005 strain of wild-type marine bacteria under corresponding conditions, as well as to a pharmaceutical composition based on it.
EFFECT: new compounds and a pharmaceutical composition based on them are obtained, which can be used in medicine for the treatment of malignant neoplasm selected from lung cancer, colon cancer, breast cancer and pancreatic cancer.
16 cl, 10 dwg, 2 tbl, 8 ex
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Authors
Dates
2022-05-30—Published
2018-03-16—Filed