METHOD FOR COMBINED TREATMENT OF STOMACH CANCER WITH LIMITED PERITONEAL DISSEMINATION Russian patent published in 2021 - IPC A61B17/00 A61K31/282 A61K31/505 A61K31/519 A61K31/337 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to oncology, can be used in the treatment of disseminated gastric cancer. The treatment is carried out in 3 stages. After verification of limited peritoneal carcinomatosis with PCI less than 7, 4 courses of chemotherapy are carried out according to the FLOT scheme, and in the presence of positive dynamics according to laparoscopy, the surgical stage of treatment is performed. 4 weeks after the end of chemotherapy, surgery is performed in the volume of gastrectomy with extended D2 lymphadenectomy. Then, two 11 mm trocars are inserted into the mesogastrium, layer-by-layer suturing of the laparotomic wound is performed, carboperitoneum 12 mm Hg is applied. A laparoscope is inserted into one of the trocars, a mechanical nozzle is connected to a high-pressure injector using an infusion line and introduced into an additional trocar and the supply of chemotherapy solutions in the form of an aerosol is started. Therapeutic pneumoperitoneum is maintained for 30 minutes at 37 degrees. 4 weeks after the operation, in the absence of severe postoperative complications and other contraindications, the patients undergo 4 more courses of polychemotherapy according to the FLOT scheme.

EFFECT: method provides stable stabilization and partial resorption of tumor foci in incurable patients, which implies improvement of long-term results due to long-term maintenance of therapeutic pneumoperitoneum and direct action of drugs on tumor cells with reaching maximum concentration in tumor-affected foci without systemic toxicity.

1 cl, 1 dwg, 1 ex