FIELD: biotechnology; medicine.
SUBSTANCE: invention relates to biotechnology and medicine, and it is a method for causing an immune response in a human against Clostridium difficile infection, including the administration to a human of an effective dose of a composition containing C. difficile toxoid with an amino acid sequence SEQ ID NO: 4, where initial methionine is absent, and C. difficile toxoid with an amino acid sequence SEQ ID NO: 6, where initial methionine is absent. In this case, the composition is administered at least three times, while the second administration is performed about 30 days after the first administration, and the third administration is performed about 180 days after the first administration. At the same time, an immune response against C. difficile toxin A and toxin B remains for at least 60 days. In this case, the composition leads to a concentration of a neutralizing antibody specific for toxin B, which is at least 2 times higher in a human after the administration of the third dose, than a concentration of neutralizing antibodies specific to toxin B in a human receiving the third dose about 30 days after the first dose, when measured under identical conditions in cytotoxicity analysis.
EFFECT: obtaining a composition for causing an immune response against Clostridium difficile.
27 cl, 9 dwg, 5 tbl, 11 ex
Title | Year | Author | Number |
---|---|---|---|
COMPOSITIONS RELATED TO MUTANT TOXIN CLOSTRIDIUM DIFFICILE AND THEIR APPLICATION METHODS | 2017 |
|
RU2773880C1 |
COMPOSITIONS RELATED TO MUTANT TOXIN CLOSTRIDIUM DIFFICILE AND THEIR APPLICATION METHODS | 2012 |
|
RU2754446C2 |
METHODS AND COMPOSITIONS FOR INDUCTION OF IMMUNE RESPONSE AGAINST CLOSTRIDIUM DIFFICILE | 2018 |
|
RU2781057C2 |
NEW CAPSID PROTEINS OF ADENO-ASSOCIATED VIRUS | 2017 |
|
RU2779318C2 |
MULTIVALENT PD-L1-BINDING COMPOUNDS FOR TREATING MALIGNANT NEOPLASMS | 2020 |
|
RU2816646C2 |
COMPOSITIONS AND METHODS FOR SELECTIVE PROTEIN EXPRESSION | 2017 |
|
RU2795467C2 |
ADENOVIRUSES AND METHODS FOR ADENOVIRUS APPLICATION | 2019 |
|
RU2782528C1 |
INSECTICIDAL PROTEINS | 2018 |
|
RU2761666C2 |
FUSED MOLECULES DERIVED FROM CHOLIX-TOXIN FOR ORAL DELIVERY OF BIOLOGICALLY ACTIVE LOADS | 2015 |
|
RU2723178C2 |
MODULATION OF REP PROTEIN ACTIVITY WHEN PRODUCING CLOSED-END DNA (ceDNA) | 2020 |
|
RU2812850C2 |
Authors
Dates
2022-06-14—Published
2018-09-14—Filed