FIELD: medicine.
SUBSTANCE: invention relates to methods and compositions for induction of an immune response against C. difficile. In specific aspects, compositions are vaccines containing multimeric polypeptides containing fragments of several bacterium toxins.
EFFECT: these polypeptides induce an effective immune response, thereby providing the treatment or prevention of an infection.
25 cl, 1 tbl, 26 dwg, 10 ex
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