METHOD FOR TREATMENT OF INFLAMMATORY DISEASES WITH MULTIVALENT Fc COMPOUNDS Russian patent published in 2022 - IPC A61K39/395 A61P37/00 G01N33/53 

FIELD: medicine.

SUBSTANCE: group of inventions relates to the field of medicine, namely to therapy; it is intended for the treatment of an inflammatory or autoimmune disease. A method for the treatment of an inflammatory or autoimmune disease in a patient with a diagnosed inadequate response to a multi-Fc therapeutic agent includes the administration of the first cumulative increased dose of the multi-Fc therapeutic agent at a dose of at least 105% of the initial dose of the specified multi-Fc therapeutic agent during the first dosing period. At the same time, the patient was diagnosed with (a) iC3b level in the blood less than the specified threshold value, after the administration of the multi-Fc therapeutic agent; or (b) percent of changing iC3b level in the blood less than 10% of the base iC3b level. In this case, the multi-Fc therapeutic agent is capable of providing multivalent Fc fragments for components of a complement system. A method for the determination of an effective dose of a multi-Fc therapeutic agent is also proposed.

EFFECT: use of the group of inventions allows for optimizing therapeutically beneficial effects, minimizing the risk of undesired side effects.

53 cl, 9 dwg, 5 ex