FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to obtaining peptide homodimers and multimers for binding to a component of the complement system C1q, and can be used in medicine for treating or preventing rheumatoid arthritis. Constructed is a peptide homodimer consisting of two identical monomers, wherein each monomer consists, in the direction from the amino-to-carboxyl end, of a multimerisation domain of the hinge region of IgG2, consisting of an amino acid sequence under SEQ ID NO: 4, and an IgG1 Fc domain consisting of the amino acid sequence under SEQ ID NO: 2 with point mutations including S267E, H268F and S324T based on the EC index according to Kabat.
EFFECT: invention provides obtaining a peptide homodimer which binds to complement C1q and inhibits CDC.
9 cl, 63 dwg, 12 tbl, 14 ex
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