FIELD: biotechnology.
SUBSTANCE: disclosed are dimeric compounds for forming multimers containing identical monomers. Each monomer contains from N-end to C-end monomer of multimerizing region and monomer of Fc-domain, which upon dimerization with another Fc-domain monomer forms a Fc-domain capable of binding to Fcγ-receptor and/or neonatal Fc-receptor (FcRN). Also disclosed are multimeric compounds for reproducing an effector function of aggregated IgG containing two to five multimerized dimeric compounds. Invention also relates to a method of treating an autoimmune disease involving administering said dimeric or multimeric compounds.
EFFECT: invention enables to obtain immunologically active biomimetics.
13 cl, 46 dwg, 5 tbl, 25 ex
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