FIELD: biotechnology.
SUBSTANCE: group of inventions is described, including a composition for use in the treatment or prevention of an inflammatory, autoimmune, or infectious disease or disorder in a subject who needs it (options), a method for the production of a composition (options), and a method for purification of a composition (options). In one of implementations, the composition contains homodimer obtained by a recombinant method and homodimer multimer, wherein homodimer contains two monomers, each of which contains a sequence SEQ ID NO: 4, wherein homodimer does not contain an antigen-binding domain.
EFFECT: invention expands the arsenal of remedies for use in the treatment or prevention of an inflammatory, autoimmune, or infectious disease or disorder in a subject.
35 cl, 51 dwg, 17 tbl, 16 ex
Title | Year | Author | Number |
---|---|---|---|
HYBRID PROTEINS OF HUMAN PROTEIN FRAGMENTS TO CREATE ORDERED MULTIMERIZED COMPOSITIONS OF IMMUNOGLOBULIN FC REGIONS WITH ENHANCED BINDING WITH A COMPLEMENT SYSTEM | 2016 |
|
RU2737378C2 |
METHOD FOR TREATMENT OF INFLAMMATORY DISEASES WITH MULTIVALENT Fc COMPOUNDS | 2017 |
|
RU2774318C2 |
TRIFUNCTIONAL ANTIGEN-BINDING MOLECULE | 2015 |
|
RU2753882C2 |
METHODS FOR CULTIVATION OF CELLS AND SETS AND DEVICE FOR THEM | 2016 |
|
RU2778411C2 |
METHODS, SETS, MEANS AND DEVICES FOR TRANSDUCTION | 2016 |
|
RU2761555C2 |
IMMUNOGLOBULIN CONSTANT REGION FC-RECEPTOR BINDING AGENTS | 2008 |
|
RU2729829C2 |
ANTIBODY PURIFICATION | 2019 |
|
RU2812161C2 |
OLIGOMERIC REAGENTS IN FORM OF PARTICLES AND THEIR APPLICATION METHODS | 2018 |
|
RU2777989C2 |
METHODS FOR CELL CULTIVATION AND SETS AND DEVICE FOR THEM | 2016 |
|
RU2761557C2 |
DEVELOPMENT OF STABLE HETERODIMERIC ANTIBODY WITH MUTATIONS IN Fc DOMAIN | 2012 |
|
RU2810540C2 |
Authors
Dates
2023-02-15—Published
2017-12-08—Filed