FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and is a modified protein for the treatment of a disease treatable by asparagine depletion, where the specified modified protein is a tetramer, and each monomer of the specified tetramer contains: (i) L-asparaginase having at least 95% identity of the amino acid sequence SEQ ID NO: 1, and (ii) one or more (poly)peptides, where the (poly)peptide consists of 20-600 amino acid residues of proline and alanine.
EFFECT: invention makes it possible to effectively treat diseases that can be treated by asparagine depletion.
18 cl, 9 dwg, 5 tbl, 9 ex
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