FIELD: chemistry.
SUBSTANCE: invention relates to the field of organic chemistry and pharmacology, namely, to derivatives of 2′-oxo-1,2′-dihydro-9aH-spiro[pyrido[2,1-b][1,3]oxazine-2,3′-pyrrole] by the general formula
wherein R=C6H4Me-4, R1=R2=COOMe, R3=OMe (a); R=Bn, R1=Ph, R2=COPh, R3=Ph (b); R=Ph, R1=C6H4Br-4, R2=H, R3=OMe (c).
EFFECT: production of new compounds exhibiting antimicrobial activity, usable as source products for synthesising heterocyclic systems and in pharmacology as potential medicinal products with antimicrobial properties.
1 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| 10-BENZYL-3,4-DIBENZOYL-2'-OXO-1',2',10,10A-TETRAHYDROSPIRO[BENZO[4,5]IMIDAZO[2,1-B][1,3]OXAZINE-2,3'-PYRROLES] |
2017 |
- Maslivets Andrej Nikolaevich
- Dmitriev Maksim Viktorovich
- Balandina Svetlana Yurevna
- Moroz Anna Andreevna
|
RU2668969C1 |
| INTERMEDIATE PRODUCTS - METHYL 7-ARYL-4, 9-DIAROYL-3-HYDROXY-1-(2-HYDROXYPHENYL)-2,6-DIOXO-1, 7-DIAZASPIRO[4,4]NONE-3, 8-DIENE-8-CARBOXYLATES; METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4,10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO[6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHOD OF PRODUCING METHYL 6, 9-DIARYL-11-AROYL-2-(O-HYDROXYPHENYL)-3, 4, 10-TRIOXO-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATES; METHYL 11-BENZOYL-2-O-HYDROXYPHEHYL-3, 4, 10-TRIOXO-9-P-TOLYL-6-PHENYL-7-OXA-2, 9-DIAZATRICYCLO [6.2.1.0]UNDEC-5-ENE-8-CARBOXYLATE HAVING ANTIMICROBIAL ACTIVITY |
2008 |
- Racheva Nadezhda L'Vovna
- Maslivets Andrej Nikolaevich
- Aleksandrova Galina Arsent'Evna
|
RU2383550C1 |
| 2'-AMINO-2,5'-DIOXO-5-PHENYL-1,2,5',6',7',8'-HEXAHYDRO-1'H-SPIRO[PYRROL-3,4'-QUINOLINES] |
2020 |
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- Dmitriev Maksim Viktorovich
- Balandina Svetlana Yurevna
- Sabitov Andrej Aleksandrovich
- Salnikova Tatyana Vladislavovna
|
RU2743922C1 |
| (1'S*,2'R*,3R*,7A'S*)-2'-NITRO-1',2',5',6',7',7A'-HEXAHYDROSPIRO[PYRROL-3,3'-PYRROLISIN]-2(1H)-ONES |
2020 |
- Maslivets Andrej Nikolaevich
- Dmitriev Maksim Viktorovich
- Balandina Svetlana Yurevna
- Moroz Anna Andreevna
|
RU2742883C1 |
| APPLICATION OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYALKYL)-1,3-DIALKYL-2-THIOXO-1,3,6-TRIAZASPIRO[4.4 NON-8-ENE-4,7-DIONES AS AGENTS WITH ANTIMICROBIAL ACTIVITY |
2021 |
- Maslivets Andrej Nikolaevich
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|
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| ANTI-TUBERCULOSIS AGENT BASED ON 4-((HET)AROYL)-3-HYDROXY-1-(2-HYDROXYPHENYL)-5-(PHENYLTHIO)-1,5-DIHYDRO-2H-PYRROL-2-ONES |
2021 |
- Mashevskaya Irina Vladimirovna
- Balandina Svetlana Yurevna
- Lukmanova Dzhamilya Nailevna
|
RU2767542C1 |
| METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-1,6-DIPHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHYL 3-METHYL-5-[2-(4-ARYLAMINO)-2-OXOACETYL]-6-STYRYL-1-PHENYL-1H-PYRAZOLO[3,4-b]PYRIDINE-4-CARBOXYLATES AND METHOD FOR PREPARING THEM |
2012 |
- Maslivets Andrej Nikolaevich
- Bubnov Nikolaj Vladimirovich
- Silajchev Pavel Sergeevich
- Filimonov Valerij Olegovich
- Makhmudov Ramiz Ragibovich
|
RU2495039C1 |
| NOVEL CONDENSED PYRIDINE DERIVATIVES USED AS C-MET TYROSINE KINASE INHIBITORS |
2013 |
- Hu, Shaojing
- Wang, Fei
- Xu, Zhiguo
- Wang, Yinxiang
- Wang, Yanping
|
RU2619130C2 |
| APPLICATION OF 2-[(R-BENZYLIDENE)HYDRAZONO]-8-HYDROXY-6-(2-HYDROXYPHENYL)-9-AROYL-1-THIA-3,6-DIAZASPIRO[4.4]NONA-8-EN-4,7-DIONES AS AGENTS WITH ANTI-INFLAMMATORY ACTIVITY |
2022 |
- Mashevskaia Irina Vladimirovna
- Lukmanova Dzhamilia Nailevna
- Apushkin Danila Iurevich
- Utushkina Taisiia Andreevna
- Iakushina Karolina Evgenevna
- Andreev Aleksandr Igorevich
|
RU2783241C1 |
| SPIRO CONDENSED PYRROLIDINE DERIVATIVES AS INHIBITORS OF DEUBIQUITINATING ENZYMES (DUB) |
2017 |
- Kemp Mark Ien
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- Dzhons Elison
|
RU2730552C2 |
