FIELD: biotechnology.
SUBSTANCE: invention relates to an isolated polynucleotide encoding a polypeptide containing a chimeric antigen receptor for CD19 (CAR), in which the polypeptide does not contain a rituximab binding site, and wherein the polynucleotide comprises a short EF1a promoter which is capable of expressing a chimeric antigen receptor for CD19 (CAR) in a mammalian T cell, as well as to a vector and a T-cell containing it. Also disclosed is a pharmaceutical composition containing said cell.
EFFECT: invention is effective for treating a disease or disorder associated with high CD19 levels in a subject.
25 cl, 13 dwg, 5 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
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| CHIMERIC ANTIGEN RECEPTORS AND WAYS OF USE THEREOF | 2020 |
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| METHODS FOR PRODUCING CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTOR | 2015 |
|
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| CELL | 2015 |
|
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| CD20 THERAPY, CD22 THERAPY AND COMBINATION THERAPY WITH CELLS EXPRESSING CHIMERIC ANTIGEN RECEPTOR (CAR) K CD19 | 2016 |
|
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| COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY | 2013 |
|
RU2832516C2 |
| NEW CHIMERIC ANTIGEN RECEPTOR CONSTRUCTS CONTAINING TNFR2 DOMAINS | 2019 |
|
RU2808254C2 |
