INHIBITOR OF LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1 (LFA-1), ITS PRODUCTION METHODS AND ITS POLYMORPH Russian patent published in 2022 - IPC C07D405/10 A61K31/4725 A61P29/00 

Abstract RU 2778771 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a method for purification of a compound of the formula I, including stages of: a) obtaining an unpurified compound of the formula I or its salt and recrystallization of the specified unpurified compound, using an acetone aqueous solution, by dissolution of the unpurified compound of the Formula I in 30% acetone aqueous solution with heating to 40-45°C, filtration of the resulting solution, and cooling of the specified solution to 18-22°C; and b) isolation of the specified compound of the formula I or its salt by removal of the acetone aqueous solution.

EFFECT: new method for purification of a compound of the formula I is developed, which allows for obtaining a compound of the formula I with increased purity.

8 cl, 10 dwg, 11 ex

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RU 2 778 771 C2

Authors

Zeller, Dzhejms, Robert

Venkatraman, Sripati

Brot, Elizabet, K.A.

Ier, Subashri

Kholl, Majkl

Dates

2022-08-24Published

2013-07-25Filed