NANOCOMPOSITES BASED ON GADOLINIUM-CONTAINING COMPOUNDS FOR DIAGNOSIS, THERAPY, AND THERANOSTICS OF ONCOLOGICAL DISEASES OF THE BRAIN AND METHODS FOR PRODUCTION THEREOF Russian patent published in 2022 - IPC C01F17/224 C01F17/30 A61K49/12 A61K49/18 A61K33/244 A61K33/26 B82B3/00 B82Y5/00 B82Y30/00 B82Y40/00 C08B37/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention can be used to produce water-soluble magnetopaque agents for the diagnosis, therapy, and theranostics of oncological diseases of the brain. Magnetopaque media constitute gadolinium-containing nanocomposites wherein the stabilising and transport matrix consists of macromolecules of a polysaccharide selected from arabinogalactan and raw arabinogalactan. The nanoparticles encapsulated in the matrix consist of Gd₂O₃, GdBO₃, or constitute Gd and Fe-containing bimetallic nanoparticles. The nanoparticles are 1 to 100 nm in size. The range of gadolinium content in the nanocomposites is 1.7 to 18 wt.%. Proposed are methods for producing nanocomposites containing Gd₂O₃, GdBO₃, or bimetallic nanoparticles Gd and Fe.

EFFECT: possibility of simplifying the production of stable magnetopaque media preserving the properties thereof for a long time and suitable for double-channel theranostics of neoplasms.

4 cl, 2 dwg, 1 tbl, 9 ex