MICROFLUIDIC SYNTHESIS OF NANOCOMPOSITE BASED ON LUMINOPHORE BaGdF:Tb AND A ROSE BENGAL PHOTOSENSITIZER FOR USE IN X-RAY PHOTODYNAMIC THERAPY OF TUMOURS Russian patent published in 2024 - IPC C09K11/55 C09K11/85 B82B3/00 B82Y5/00 B82Y30/00 B82Y40/00 A61K49/04 

FIELD: chemistry.

SUBSTANCE: invention is intended to produce an agent used in medicine in X-ray photodynamic therapy of tumours. During microfluidic synthesis of nanocomposite based on luminophore BaGdF₅:Tb and a rose bengal photosensitizer, precursors are first prepared by dissolving in separate flasks the chlorides BaCl₂, GdCl₃ and NH₄F in 50 ml of an ethylene glycol-water mixture with a volume ratio of its components of 3:1, and concentration of 0.1 M, as well as a precursor of the doping element TbCl₃ in 10 ml of said mixture. Also, an aqueous solution of rose bengal with concentration of 62.5 mcg/ml in 50 ml of said mixture is prepared. Prepared solutions of precursors are introduced by means of system of syringe pumps 1 separately into each channel of four-channel microreactor 2 with specified flow rates in mcl/s: BaCl₂ – 10.28, GdCl₃ – 7.71, TbCl₃ – 2.57, NH₄F – 10.28 and mixing them in the meander of said microreactor 2 at a rate of propagation of the reaction mixture of 30.84 mcl/s. Prepared reaction mixture is thermostated in oil bath 3 at temperature of 100 °C to obtain a suspension of luminophore crystals corresponding to chemical formula BaGd_0.75F₅:Tb_0.25, and then cooled in water bath 4. Using syringe pump 6, an aqueous solution of rose bengal is introduced into one channel of two-channel microreactor 5 at a rate of distribution of 30.84 mcl/s with simultaneous introduction of a cooled suspension of luminophore crystals into another channel and mixing them in a meander of said two-channel microreactor 5 to obtain a nanocomposite based on said luminophore and a rose bengal photosensitizer. Nanocomposite suspension is then fed into receiving flask 7. Collected product is centrifuged at 13,000 rpm to remove weakly bound or unbound photosensitizer molecules. Synthesized nanoparticles are washed four times with twice distilled water.

EFFECT: invention enables to obtain said nanocomposite by conjugating synthesized luminophore nanoparticles with photosensitizer molecules in a single-step microfluidic synthesis.

1 cl, 2 tbl, 5 dwg