METHOD FOR OBTAINING A DERIVATIVE OF 7H-PYRROLO[2,3-D] PYRIMIDINE AND ITS INTERMEDIATE Russian patent published in 2021 - IPC C07D519/00 C07D487/04 C07D487/10 C07D205/04 

FIELD: pharmaceutics.

SUBSTANCE: presented group of inventions relates to a new compound, namely, disodium salt dihydrate of a compound [10], represented by the formula [9], or its crystalline form, demonstrating a powder X-ray diffractogram having peaks with a diffraction angle (2θ): 4.9°±0.2°, 12.3°±0.2°, 14.2°±0.2°, 14.5°±0.2°, 15.0°±0.2°, 15.5°±0.2°, 16.5°±0.2°, 18.1°±0.2°, 18.4°±0.2°, 18.6°±0.2°, 19.2°±0.2°, 20.0°±0.2°, 21.3°±0.2° or 22.7°±0.2°, 23.3°±0.2° and 24.8°±0.2°, when using CuKα-radiation. In addition, a method for obtaining disodium salt dihydrate, represented by the formula [9], is described, including the cleavage of tert-butyl from a compound of the formula [8] by processing it with acid selected from p-toluene sulfonic acid or phosphoric acid, where acid is used in amount of 1.0 to 3.0 equivalents relatively to the compound of the formula [8] and where a reaction is carried out in the presence of a solvent selected from acetonitrile, water or a mixture of these solvents; where the reaction temperature is from 40 to 60°C and where the reaction time is from 5 to 24 hours; with the subsequent formation of a compound of the formula [9] with sodium hydroxide.

EFFECT: technical result is that a new compound is obtained and described, which can be used as an intermediate compound in a method for producing a derivative of 7H-pyrrolo[2,3-d]pyrimidine, which can be used as a Janus kinase (JAK) inhibitor.

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5 cl, 6 dwg, 8 tbl, 32 ex