FIELD: organic chemistry.
SUBSTANCE: options for obtaining the free base of compound A of formula 1 are proposed, including the stage of converting 2-isopropylphenol into a co-crystal of 4-bromo-2-isopropylphenol and hemi-DABCO, additionally including the stage of converting a co-crystal of 4-bromo-2-isopropylphenol and hemi-DABCO into a methoxyphenol compound, further comprising the step of reacting 2-isopropyl-4-methoxyphenol with ClCH2CN to produce a cyanoether compound, 2-(2-isopropyl-4-methoxyphenoxy)acetonitrile.
EFFECT: development of a simple method for obtaining the free base of compound A with high yield.
11 cl, 11 dwg, 1 ex
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