METHODS FOR TREATMENT OF COLORECTAL AND METASTATIC COLORECTAL CANCER Russian patent published in 2022 - IPC A61K31/519 A61K31/513 A61K31/4745 A61K39/00 A61P35/00 

FIELD: medicine; oncology.

SUBSTANCE: invention relates to the field of medicine, namely to oncology; it is intended for the treatment of colorectal cancer. [6R]-5,10-methylenetetrahydrofolate (hereinafter – 6R-MTHF) is used for the treatment of a patient with diagnosed colorectal cancer or metastatic colorectal cancer. The specified treatment includes the administration of a pharmaceutical composition containing bevacizumab at a dose of 5 mg/kg of bevacizumab by intravenous infusion; subsequent administration of a pharmaceutical composition containing oxaliplatin at a dose of 85 mg/m² of oxaliplatin by intravenous infusion; subsequent administration of a pharmaceutical composition containing 5-fluorouracil (hereinafter – 5-FU) at a dose of 400 mg/m² of 5-FU in the form of intravenous bolus; subsequent administration of a pharmaceutical composition containing 6R-MTHF at a dose of 60 mg/m² of 6R-MTHF by means of intravenous bolus; subsequent administration of the pharmaceutical composition containing 5-fluorouracil (5-FU) at a dose of 2400 mg/m² of 5-FU by intravenous infusion during 46 hours; and administration of the pharmaceutical composition containing 6R-MTHF at a dose of 60 mg/m² of 6R-MTHF by means of intravenous bolus.

EFFECT: use of the invention allows for the reduction in disease progression, maintenance of the disease in a stable condition, as well as provides the improvement of the total response frequency compared to standard treatment methods, in which folates are used, such as folic acid.

16 cl, 12 ex