METHODS FOR INCREASING LEVEL OF 2'-DEOXYURIDINE (DURD) IN PLASMA AND INHIBITING THYMIDYLATE SYNTHASE Russian patent published in 2022 - IPC A61K39/395 A61K31/4745 A61K31/513 A61K31/555 A61K45/06 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely to a method for increasing levels of 2’-deoxyuridine (hereinafter – dUrd) in plasma of a human subject. The method for increasing the concentration of 2’-deoxyuridine (dUrd) in plasma of a human subject includes: a stage (a) of injection of 400 mg/m² or 500 mg/m² of 5-fluorouracil (hereinafter – 5-FU) intravenously in the form of a bolus injection to a human subject; after the stage (a), a stage (b) of intravenous injection of 30, 60, 120 or 240 mg/m² of [6R]-5,10-methylenetetrahydrofolate (hereinafter – 6R-MTHF) intravenously in the form of two bolus injections to the specified human subject, and (c) optional injection of 2400 mg/m² of 5-FU in the form of continuous infusion simultaneously with the stage (b) or after it.

EFFECT: above-described method allows for significantly increasing dUrd in blood plasma in a joint injection of an equimolar dose of 6R-MTHF with 5-FU compared to a drug.

11 cl, 4 dwg, 2 tbl, 2 ex