FIELD: biochemistry.
SUBSTANCE: invention relates to the field of biochemistry, in particular to a protein structure, as well as to its production method. The specified structure contains at least one mutated Fab-fragment.
EFFECT: invention provides for the formation of corresponding pairs of heavy/light chains and prevents the formation of their erroneous pairing.
15 cl, 11 dwg, 6 ex
Title | Year | Author | Number |
---|---|---|---|
MOLECULES BINDING WITH CD38 AND PD-L1 | 2017 |
|
RU2764201C2 |
POLYPEPTIDE LINKER FOR PRODUCTION OF MULTI-SPECIFIC ANTIBODIES | 2018 |
|
RU2776302C2 |
TRISPECIFIC BINDING PROTEINS BINDING CD38, CD28 AND CD3, AS WELL AS METHODS OF USE FOR TREATING VIRAL INFECTION | 2019 |
|
RU2820351C2 |
ANTIBODIES TO CD38 AND COMBINATIONS WITH ANTIBODIES TO CD3 AND CD28 | 2018 |
|
RU2812910C2 |
HIGH-AFFINITY ANTI-PD-1 AND ANTI-LAG-3 ANTIBODIES AND BISPECIFIC BINDING PROTEINS OBTAINED FROM THEM | 2019 |
|
RU2782381C2 |
TUMOR-TARGETED AGONISTIC CD28-ANTIGEN-BINDING MOLECULES | 2019 |
|
RU2808030C2 |
ANTIBODIES BINDING TO CD3 | 2019 |
|
RU2810924C2 |
COMBINATION CANCER THERAPIES TARGETTING CD38 AND TGF-BETA | 2019 |
|
RU2808632C2 |
ANTIBODY-LIKE BINDING PROTEINS WITH DOUBLE VARIABLE REGIONS HAVING CROSS-CROSS ORIENTATION OF BINDING REGIONS | 2012 |
|
RU2823693C2 |
BINDING MOLECULES INDUCING CELLULAR ACTIVATION | 2019 |
|
RU2770620C1 |
Authors
Dates
2022-09-12—Published
2018-03-27—Filed