ORGANIC COMPOUNDS Russian patent published in 2021 - IPC C07D471/16 A61K31/4985 A61P25/00 

FIELD: medicine; pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula I in a free or pharmaceutically acceptable salt form which can be used as serotonin (5-HT_2A) modulator, dopamine (D1) and mu-opioid receptors. In the compound of formula IX is -NH-; L is O; Z is -CH(OR₁)-, -O- or -C(=O)-; R₁ is H. Invention also relates to a pharmaceutical composition for treating a central nervous system disorder involving serotonin 5-HT_2A pathways, serotonin reuptake (SERT) transporter, dopamine D1 or mu-opioid receptor containing a therapeutically effective amount of the compound of formula I. Also described is a method of treating or preventing central nervous system disorders involving serotonin 5-HT_2A, serotonin reuptake (SERT), dopamine D1 or mu-opioid receptor. Proposed method comprises administering to patient in need thereof a compound or pharmaceutical composition of invention.

formula I

EFFECT: compounds and pharmaceutical compositions of the invention can be used for preparing a drug for treating or preventing the above disorders of the central nervous system.

20 cl, 4 tbl, 8 ex