FIELD: medicine.
SUBSTANCE: each pellet comprises a water-soluble core, a naltrexone-containing antagonist layer coating the core, a polymer barrier coating the antagonist layer, an Oxycodone-containing agonist layer coating the polymer barrier and a control release layer coating the agonist layer.
EFFECT: drug preparation is applicable to release respiratory distress in an individual which is observed in case of a pre-administration damage of the drug preparation, by naltrexone release.
8 cl, 5 dwg, 3 tbl, 4 ex
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