ORGANIC COMPOUNDS Russian patent published in 2023 - IPC C07J43/00 C07J1/00 A61K31/58 A61P23/00 A61P25/20 

FIELD: organic chemistry; pharmacology.

SUBSTANCE: group of inventions is aimed at the treatment or prevention of a disorder of the central nervous system that can be alleviated using a GABAA receptor modulator. The following is disclosed: a compound of formula I, wherein X is selected from H; R¹ is selected from CH₃ and CD₃; each of R²-R⁹ is independently selected from H and D; either in free form or in the form of a pharmaceutically acceptable salt, provided that at least one of R⁴-R⁹ is D. Additionally the following is disclosed: a pharmaceutical composition for the treatment or prevention of a central nervous system disorder amenable to amelioration by a GABAA receptor modulator containing a therapeutically effective amount of the above compound, with a method of treating or preventing a central nervous system disorder amenable to relief by a GABAA receptor modulator, comprising administering to a patient in need thereof, a method of inducing sedation or anesthesia in the patient in need thereof, wherein the method includes administering a compound of formula I to a patient in need thereof, as well as using this compound in the manufacture of a medicinal product.

EFFECT: group of inventions provides effective treatment of the central nervous system disorders associated with the GABAA receptor.

29 cl, 3 tbl, 16 ex