ORGANIC COMPOUNDS Russian patent published in 2016 - IPC C07D471/16 C07D491/147 A61K31/437 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to specific substituted condensed with heterocycle gamma-carbolynam of formula I, where X is -N(H)- or -N(CH₃) and Y represents -C(H)(OH)-; and formula III, where X is -N(CH₃)-, -N(H)-; and R₁ is selected from -C(O)-C-_1-5alkyl, -C(O)-C-₆alkyl, -C(O)-C₇alkyl and -C(O)-C₉alkyl in free form, in form of solid substance, in form of pharmaceutically acceptable salts and/or in substantially pure form, as well as to pharmaceutical compositions based on these compounds.

EFFECT: treating diseases involving 5-HT₂A receptor, carrier serotonin (SERT) and/or path, involving dopamine D2 receptor system signal.

30 cl, 2 dwg, 2 tbl, 9 ex