PREPARATION METHOD FOR THE SYNTHESIS OF S-NICOTINE FROM GLUTARATE Russian patent published in 2022 - IPC C07D401/04 A24B15/10 

FIELD: smoking accessories.

SUBSTANCE: invention relates to a method for preparing S-nicotine from glutarate, including: the reaction of nicotinate with glutarate in the presence of a main catalyst to produce 5-carbonyl-5-(pyridine-3-yl) pentanoic acid, the reaction with an aminating reagent to produce 5-oxo-5-(pyridine-3-yl)pentanamide, implementation of Hoffmann rearrangement to obtain 4-amino-1-(pyridine-3-yl)butanone, reduction of the carbonyl group of 4-amino-1-(pyridine-3-yl)butanone using (+)-B-diiso-pinocamphail-chlor-borane to obtain (S)-4-amino-1-(pyridine-3-yl)butane-1-ol, the implementation of chlorination and cyclization to obtain S-demethylnicotine and, finally, the implementation of methylation of amine to obtain S-nicotine.

EFFECT: new method for producing S-nicotine has been developed, which has the advantages of a simple operation, easily accessible raw materials, high yield, high enantiomeric purity, milder reaction conditions, simple processing methods during the reaction, etc. and is more suitable for industrial production.

10 cl, 7 tbl