FIELD: medicine and digital signal processing.
SUBSTANCE: invention relates to medicine and digital signal processing and can be used in biomedical research based on animal models of epileptic processes, including studies related to the early diagnosis of epilepsy and the effect of pharmacological drugs on epileptic processes. A method for detecting immature discharges in epilepsy in laboratory rats includes implanting electrodes into the skull of a rat and recording an electroencephalogram (EEG) from the implanted electrodes. The main electrode is implanted in the left part of the skull bone above the frontal area of the rat cerebral cortex, and the reference electrode is implanted in the skull bone located above the cerebellum. The registered EEG signal is divided into fragments according to time. Wavelet spectrograms of EEG signal fragments are determined with selection of local maxima characterizing bursts of wavelet spectrograms. Define burst parameters. The number of bursts per second is determined, the parameters of which correspond to the ranges predetermined from the data of rats with confirmed epilepsy. For each fragment of the EEG signal, the value of the coefficients C1 and C2 is calculated, which are compared with the threshold values T1 and T2, respectively. If both coefficients are simultaneously less than the threshold values, the corresponding fragment of the EEG signal is classified as an immature discharge.
EFFECT: rapid and accurate detection of immature discharges in laboratory rats is achieved using the analysis of burst-like electrical activity of the brain with high specificity and sensitivity of recognition of immature discharges, excluding operations that depend on the opinion of an expert from the analysis of experimental data, which contributes to the standardization of biomedical research.
4 cl, 7 dwg, 1 ex, 2 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF DIFFERENTIAL DIAGNOSIS OF ESSENTIAL TREMOR AND THE FIRST STAGE PARKINSON'S DISEASE USING SPURGE ANALYSIS ON CROSS-WAVELET SPECTRUM OF ELECTROMYOGRAPHIC SIGNALS OF ANTAGONIST MUSCLES | 2022 |
|
RU2797878C1 |
| METHOD FOR DIFFERENTIAL DIAGNOSIS OF ESSENTIAL TREMOR AND EARLY AND FIRST STAGES OF PARKINSON'S DISEASE BY ANALYSING FLARE-LIKE ACTIVITY OF MUSCLES | 2020 |
|
RU2741233C1 |
| METHOD OF EARLY ENCEPHALOGRAPHIC DIAGNOSTICS OF PARKINSON DISEASE | 2012 |
|
RU2484766C1 |
| METHOD FOR AUTOMATIC ISOLATION OF PHYSIOLOGICAL STATES OF SMALL LABORATORY ANIMALS | 2020 |
|
RU2751744C1 |
| METHOD OF ISOLATION OF SPINDLE-SHAPED PATTERNS BY TIME DATA OF ELECTROENCEPHALOGRAMS | 2014 |
|
RU2565993C1 |
| INTERLEUKIN-10, USING IT AND BASED COMPOSITION FOR TREATING BRAIN NEURODEGENERATIVE PROCESSES | 2012 |
|
RU2538613C2 |
| DIAGNOSTIC TECHNIQUE FOR EPILEPSY | 2014 |
|
RU2562109C1 |
| METHOD OF SURGICAL TREATMENT OF TEMPORAL EPILEPSY | 2017 |
|
RU2646748C1 |
| METHOD OF ALLOCATION OF CHARACTERISTIC PHASES OF SYSTEMS BEHAVIOUR ACCORDING TIME DATA | 2007 |
|
RU2337610C1 |
| 4-BENZOYLPYRIDINE OXIME DERIVATIVES HAVING ANTICONVULSANT ACTIVITY AS AGENTS FOR TREATMENT OF EPILEPSY AND PAROXYSMAL STATES | 2016 |
|
RU2643091C2 |
