FIELD: medicine.
SUBSTANCE: invention relates to thiophene derivatives corresponding to the following formula (I):
,
where each symbol is such as defined in the claims, or its pharmaceutically acceptable salt, which have activity of suppression of TNF-α production and activity of inhibition of proliferation of hematological malignant cells, and it is suitable for the treatment of rheumatoid arthritis, Crohn’s disease, ulcerative colitis, and, in addition, hematological malignant tumor.
EFFECT: obtaining thiophene derivatives for the treatment of diseases.
24 cl, 2 tbl, 56 ex
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