ANALGESIC COMPOUNDS Russian patent published in 2022 - IPC C07C211/38 C07C211/40 C07C215/08 C07C217/52 C07C217/62 C07C229/10 C07C229/14 C07C235/14 C07C237/04 C07C271/24 C07D213/26 C07D213/38 C07D235/14 C07D239/26 C07D263/56 C07D277/22 C07D277/28 C07D277/64 A61K31/135 A61K31/325 A61K31/4184 A61K31/423 A61K31/426 A61K31/44 A61K31/505 A61P25/04 A61P29/00 

FIELD: medicine.

SUBSTANCE: invention relates to compounds selected from compounds of formulas (Ie), (In), (Ip), (Iq), (Ir), and (Is) or their pharmaceutically acceptable salts, which can be used for reduction or at least partial prevention of pain or fever. In the specified formulas, each X¹¹, each X¹², each X¹³, and each X¹⁴ is independently unsubstituted C_1-4 alkyl or fluorine, provided that at least two of X¹¹ are fluorine, provided that at least two of X¹² are fluorine, provided that at least two of X¹³ are fluorine, and provided that at least two of X¹⁴ are fluorine; each X⁹ is independently deuterium, fluorine or chlorine; R^5F, R^5H, R^5J, R^5K, and R^5L are independently hydrogen or unsubstituted C_1-4 alkyl; R^5C is selected from a group consisting of hydrogen and C(=O)R¹²; R^4a and R^4b are independently hydrogen, unsubstituted C_1-4 alkyl, or -C(X¹⁶)₃, provided that at least one of R^4a and R^4b is -C(X¹⁶)₃; R¹² is unsubstituted C_2-30 alkenyl; each X¹⁶ is independently hydrogen or fluorine, provided that at least two of X¹⁶ are fluorine; Z¹, Z², and Z³ are independently NH, oxygen, or sulfur; p5, p11, p13, p14, p15, and p16 are 0. The invention also relates to the use of the specified compounds or their pharmaceutically acceptable salts for the production of a drug for reduction or at least partial prevention of pain or fever.

EFFECT: obtaining analgesic compounds.

20 cl, 1 dwg, 9 tbl, 28 ex