FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology and medicine. Presented is a complex of a type A toxin Clostridium botulinum, containing components HA70, HA17, HA33, NTNH, and BoNT/A1. Presented is a nucleic acid encoding the type A toxin Clostridium botulinum and a pharmaceutical composition for treating or preventing a disease caused by synaptic transmission or release of acetylcholine and for aesthetic medicine, containing the complex of the type A toxin Clostridium botulinum. Presented is a liquid agent for treating or preventing a disease caused by synaptic transmission or release of acetylcholine and for aesthetic medicine, containing the complex of the type A toxin Clostridium botulinum. Presented is an aesthetic medicine method and a method for treating or preventing a disease caused by synaptic transmission or release of acetylcholine in a subject in need thereof; an application of the complex of the type A toxin Clostridium botulinum, a pharmaceutical composition or a liquid agent when manufacturing a medicinal product, and an application of the complex of the type A toxin Clostridium botulinum, a pharmaceutical composition, or a liquid agent when manufacturing a product for aesthetic medicine.
EFFECT: compared to previously applied complexes of botulinum toxin, the botulinum toxin complex according to the present invention has a lower molecular weight, is safer, and has a significant therapeutic effect.
17 cl, 4 dwg, 18 tbl, 4 ex
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