ENGINEERED BOTULINUM NEUROTOXIN Russian patent published in 2021 - IPC C07K14/33 A61K38/48 

Abstract RU 2746736 C2

FIELD: biotechnology; medicine.

SUBSTANCE: invention relates to the field of biotechnology and medicine. The present invention discloses a botulinum neurotoxin (BoNT) polypeptide with a modified receptor binding domain (HC) having one or more amino acid mutations that modify BoNT binding to the receptor. Specific mutations and combinations of mutations are also described. Also disclosed are isolated modified nucleic acids, chimeric molecules, pharmaceutical compositions and methods for their preparation and use.

EFFECT: invention relates to one of the promising directions in the development of new methods of treatment of a number of diseases.

20 cl, 3 tbl, 1 ex, 21 dwg

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RU 2 746 736 C2

Authors

Dong Min

Peng Lisheng

Tao Liang

Dates

2021-04-20Published

2016-03-25Filed