FIELD: biotechnology.
SUBSTANCE: invention relates to virus inactivation methods. The method is used for purification of biologically active drugs, such as protein subunits, proteins (enzymes, factors, etc.), recombinant proteins, antibodies, vaccines, or gene-therapeutic products. The method for purification of a solution of a biological product having an unidentified contaminant of an enveloped virus type includes incubation of the solution of the biological product with a solution of N-methylglucamide till inactivation of the contaminant of the enveloped virus type, present in the solution of the biological product to form an inactivated contaminant of a virus type; and purification of the resulting solution of the biological product for removal of the inactivated contaminant of the virus type.
EFFECT: implementation of the invention provides an increase in the efficiency, reliability, and general safety of the resulting products.
13 cl, 17 dwg, 9 tbl, 18 ex
| Title | Year | Author | Number |
|---|---|---|---|
| VIRUS INACTIVATION METHODS FOR CONTINUOUS ANTIBODY PRODUCTION | 2019 |
|
RU2807176C2 |
| ENVIRONMENTALLY ACCEPTABLE DETERGENT FOR INACTIVATION OF VIRUSES WITH A LIPID ENVELOPE | 2018 |
|
RU2802513C2 |
| METHOD FOR LIQUID INCUBATION AND VIRAL INACTIVATION | 2018 |
|
RU2779191C2 |
| METHODS OF VIRUS INACTIVATION USING ENVIRONMENTAL-FRIENDLY DETERGENTS | 2014 |
|
RU2707951C1 |
| METHOD OF OBTAINING SAFE IN VIRUS RESPECT BIOLOGICAL FLOWING MEDIA | 2005 |
|
RU2411959C2 |
| PREPARATION OF ANTIBODY IgG AND METHOD OF ITS PRODUCTION | 2005 |
|
RU2337109C2 |
| METHOD FOR OBTAINING A TETRAVALENT VACCINE FOR THE PREVENTION OF INFLUENZA | 2020 |
|
RU2754398C1 |
| METHOD FOR PURIFICATION OF BLOOD-COAGULATION FACTOR VIII | 2009 |
|
RU2567811C2 |
| METHOD OF PURIFYING COAGULATION FACTOR VIII | 2009 |
|
RU2698392C2 |
| METHOD FOR OBTAINING A LIOPHILIZED PREPARATION OF AN ACTIVATED PROTROMBIN COMPLEX HAVING VIII-SHUNTING ACTIVITY FACTOR | 2017 |
|
RU2648517C1 |
