FIELD: biotechnology.
SUBSTANCE: invention relates to the field of biotechnology. A strain of hybrid cultured Homo sapiens/Mus musculus 1B9C7 cells producing human monoclonal antibodies specific to the domain of botulinum toxin type A (LC BoNT/A) Clostridium botulinum is described. The strain is deposited in the state collection of pathogenic microorganisms and cell cultures “GKPM-Obolensk”, collection number H-96.
EFFECT: invention expands the arsenal of means for obtaining monoclonal antibodies capable of neutralizing the proteolytic activity of LC BoNT/A, which can be used for the subsequent manufacture of a therapeutic drug.
1 cl, 5 dwg, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| THE STRAIN OF HYBRID CULTURED HOMO SAPIENS/Mus MUSCULUS CELLS Hu-C6D7-RBD IS A PRODUCER OF HUMAN MONOCLONAL ANTIBODIES SPECIFIC TO THE RBD DOMAIN S OF THE SARS-CoV-2 VIRUS PROTEIN | 2022 |
|
RU2788359C1 |
| STRAIN OF HYBRID CULTURED CELLS OF HOMO SAPIENS / MUS MUSCULUS 8D4E9-BA-LF-PRODUCER OF HUMAN MONOCLONAL ANTIBODIES AGAINST LETHAL FACTOR OF ANTHRAX AGENT | 2018 |
|
RU2699193C1 |
| STRAIN OF HYBRID CELLS OF ANIMALS Mus musculus 3F11 - PRODUCER OF MONOCLONAL ANTIBODIES SPECIFIC TO BOTULINUS TOXIN TYPE B | 2014 |
|
RU2566553C1 |
| STRAIN OF HYBRID ANIMAL CELLS Mus musculus 1G7 - PRODUCER OF MONOCLONAL ANTIBODIES SPECIFIC FOR BOTULINUM TOXIN OF TYPE B | 2014 |
|
RU2571208C1 |
| SEQUENCE OF DNA-APTAMERS, BINDING TO PROTEOLYTIC SUBUNIT OF NEUROTOXIN OF TYPE A CLOSTRIDIUM BOTULINUM | 2014 |
|
RU2571210C1 |
| METHOD OF DETERMINING BOTULINUM NEUROTOXIN OF TYPE A BASED IMMUNODETECTION, COMBINED WITH POLYMERASE CHAIN REACTION | 2013 |
|
RU2549463C1 |
| METHOD OF DETERMINING THE ACTIVITY OF BOTULINUM TOXIN USING CELLS | 2019 |
|
RU2803123C2 |
| ANTIGEN BINDING SECTION (FAB), INCLUDING HUMANIZED FAB, AGAINST BOTULINICAL NEUROTOXIN C (VERSIONS), METHOD TO OBTAIN FAB USING YEAST, METHOD AND SET FOR BOTULINICAL NEUROTOXIN C DETECTION | 2016 |
|
RU2623157C1 |
| DNA SEQUENCE OF APTAMERS BINDING SHIGA-TOXIN OF TYPE 2 | 2014 |
|
RU2566552C1 |
| EXPRESSION VECTOR BASED ON ADENO-ASSOCIATED VIRUS WITH PROTECTIVE PROPERTIES AGAINST INTOXICATION CAUSED BY BOTULINUM NEUROTOXIN TYPE A | 2021 |
|
RU2768044C1 |
