METHODS FOR IMPROVEMENT OF MEMORY AND COGNITIVE FUNCTION AND TREATMENT OF MEMORY DISORDERS AND COGNITIVE DISORDERS Russian patent published in 2022 - IPC C07D401/06 C07D413/14 A61K31/4184 A61K31/44 A61P25/28 

FIELD: pharmacology; medicine.

SUBSTANCE: invention relates to the field of pharmacology and medicine, namely to the treatment of cognitive functions in a subject. A method for the treatment for improvement of memory and/or cognitive function in a subject who needs such treatment is disclosed, including administration to the subject who needs such treatment of therapeutically effective amount of an antagonist of calcium channels of T type. In this case, the antagonist of calcium channels of T type is MK-8998 or its pharmaceutically acceptable salt. The treatment is used for a condition selected from a group consisting of agnosia, amnesia, Angelman syndrome, Asperger syndrome, autism, cerebral amyloid angiopathy, cognitive disorder caused by alcohol or medications, degenerative dementia, dementia associated with intracranial tumors, Levi’s body disease, multi-infarction dementia, Dravet syndrome, Prader-Willi syndrome, trisomy (including trisomy 21 (Down syndrome)), and Wernicke-Korsakov syndrome.

EFFECT: invention provides effective treatment of memory and/or cognitive function by administration of an antagonist of calcium channels of T type.

MK-8998

7 cl, 1 dwg, 1 tbl, 2 ex