FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to pharmaceutics and medicine, and concerns the application of a first compound that is a selective 5-HT6-receptor antagonist and a second compound that is a selective 5-HT2A-receptor antagonist wherein the first compound has affinity to the 5-HT6-receptor of the value pKi more than or equal to 8, while the second compound has affinity to the 5-HT2A-receptor of the value pKi more than or equal to 8; each of said compounds exhibits at least 30-fold selectivity to the 5-HT2C receptor, dopamine D2-receptor, histamine HI-receptor and muscarine M1 and M2 receptors, or the combined selective 5-HT6/5-HT2A-receptor antagonist for making a drug for treating a disease associated with a cognitive disorder.
EFFECT: invention provides high clinical effectiveness.
8 cl, 3 dwg, 2 tbl, 5 ex
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