BENZOTHIADIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACIDS MODULATORS Russian patent published in 2024 - IPC C07D285/36 A61K31/554 A61P1/16 A61P3/06 A61P3/08 A61P9/00 A61P35/00 

Abstract RU 2814570 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein each of R1 and R2 independently represents C1-4 alkyl; R3 is independently selected from the group consisting of hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, cyano, nitro, amino, N-(C1 -4alkyl)amino, N,N-di(C1-4alkyl)amino and N-(aryl-C1-4 alkyl)amino; n is an integer 1, 2 or 3; R4 is selected from the group consisting of hydrogen, halogen, hydroxy, cyano, C1-4 alkyl, C3-6 cycloalkyl, C1-4 alkoxy, C3-6 cycloalkyloxy, C1-4 alkylthio, C3-6 cycloalkylthio, amino, N-(C1-4alkyl) amino and N,N-di(C1-4alkyl) amino; R5A, R5B, R5C and R5D are each independently selected from the group consisting of hydrogen, halogen, hydroxy, amino and C1-4 alkyl; and R6 is selected from the group consisting of hydrogen and C1-4 alkyl. The invention also relates to a pharmaceutical composition having activity of inhibiting the apical sodium-dependent bile acid transporter (ASBT) and/or hepatic bile acid transport (LBAT), based on a compound of formula (I).

EFFECT: obtaining new compounds and a pharmaceutical composition based on them which can be used in medicine in the treatment of cardiovascular diseases, disorders of fatty acid metabolism and glucose utilization, gastrointestinal diseases and liver diseases.

15 cl, 8 tbl, 14 ex

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RU 2 814 570 C2

Authors

Gillberg, Per-Joran

Mattson, Yan

Starke, Ingemar

Kulkarni, Santosh S.

Dates

2024-03-01Published

2020-02-06Filed