BENZOTHIADIAZEPINE COMPOUNDS AND THEIR USE AS BILE ACIDS MODULATORS Russian patent published in 2024 - IPC C07D285/36 A61K31/554 A61P1/16 A61P3/06 A61P3/08 A61P9/00 A61P35/00 

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein each of R¹ and R² independently represents C_1-4 alkyl; R³ is independently selected from the group consisting of hydrogen, halogen, hydroxy, C_1-4 alkyl, C_1-4 haloalkyl, C_1-4 alkoxy, C_1-4 haloalkoxy, cyano, nitro, amino, N-(C_{1 -4}alkyl)amino, N,N-di(C_1-4alkyl)amino and N-(aryl-C_1-4 alkyl)amino; n is an integer 1, 2 or 3; R⁴ is selected from the group consisting of hydrogen, halogen, hydroxy, cyano, C_1-4 alkyl, C_3-6 cycloalkyl, C_1-4 alkoxy, C_3-6 cycloalkyloxy, C_1-4 alkylthio, C_3-6 cycloalkylthio, amino, N-(C_1-4alkyl) amino and N,N-di(C_1-4alkyl) amino; R^5A, R^5B, R^5C and R^5D are each independently selected from the group consisting of hydrogen, halogen, hydroxy, amino and C_1-4 alkyl; and R⁶ is selected from the group consisting of hydrogen and C_1-4 alkyl. The invention also relates to a pharmaceutical composition having activity of inhibiting the apical sodium-dependent bile acid transporter (ASBT) and/or hepatic bile acid transport (LBAT), based on a compound of formula (I).

EFFECT: obtaining new compounds and a pharmaceutical composition based on them which can be used in medicine in the treatment of cardiovascular diseases, disorders of fatty acid metabolism and glucose utilization, gastrointestinal diseases and liver diseases.

15 cl, 8 tbl, 14 ex