BENZOTHIA(DI)AZEPINE COMPOUNDS AND USE THEREOF AS BILE ACID MODULATORS Russian patent published in 2025 - IPC C07D281/10 C07D285/36 A61K31/554 A61P1/16 A61P3/06 A61P3/08 A61P5/00 A61P9/00 

FIELD: chemistry.

SUBSTANCE: group of inventions relates to organic chemistry and includes compounds: (Z)-3-((3-butyl-3-methyl-7-(methylthio)-1,1-dioxide-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-8-yl)oxy)-2-fluoroacrylic acid, (R)-(Z)-3-((3-butyl-3-methyl-7-(methylthio)-1,1-dioxide-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl)oxy)-2-fluoroacrylic acid, (S)-(Z)-3-((3-butyl-3-methyl-7-(methylthio)-1,1-dioxide-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl)oxy)-2-fluoroacrylic acid, (E)-3-((3-methyl-7-(methylthio)-1,1-dioxide-5-phenyl-3-propyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-8-sludge)oxy)acrylic acid, (S)-(E)-3-((3-methyl-7-(methylthio)-1,1-dioxide-5-phenyl-3-propyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl)oxy)acrylic acid, (R)-(E)-3-((3-methyl-7-(methylthio)-1,1-dioxide-5-phenyl-3-propyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl)oxy)acrylic acid, (Z)-2-fluoro-3-((3-methyl-7-(methylthio)-1,1-dioxide-5-phenyl-3-propyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl)oxy)acrylic acid, (R)-(Z)-2-fluoro-3-((3-methyl-7-(methylthio)-1,1-dioxide-5-phenyl-3-propyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl)oxy)acrylic acid, (S)-(Z)-2-fluoro-3-((3-methyl-7-(methylthio)-1,1-dioxide-5-phenyl-3-propyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-8-yl)oxy)acrylic acid, (Z)-3-((3-ethyl-3-methyl-7-(methylthio)-1,1-dioxide-5-phenyl-2,3,4,5-tetrahydro-1,5-benzothiazepine-8-yl)oxy)-2-fluoroacrylic acid, pharmaceutically acceptable salts thereof, a pharmaceutical composition based thereon and use.

EFFECT: technical result is 1,5-benzothiazepine derivatives possessing activity of inhibition of apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transporter (LBAT).

7 cl, 1 dwg, 8 tbl, 10 ex