BENZOTHIAZEPINE COMPOUNDS AND USE THEREOF AS BILE ACID MODULATORS Russian patent published in 2025 - IPC C07D281/10 A61K31/554 A61P3/06 A61P3/08 A61P5/00 A61P9/00 

Abstract RU 2838460 C1

FIELD: chemistry.

SUBSTANCE: group of inventions relates to organic chemistry and includes 1,5-benzothiazepine derivatives of formula (I), individual compounds specified in the claim, pharmaceutically acceptable salts thereof, a pharmaceutical composition based thereon and use thereof. In formula (I), R1 and R2 are each independently C1-4alkyl; R3 is independently selected from a group consisting of hydrogen, halogen, hydroxy, C1-4alkyl, C1-4haloalkyl, C1-4alkoxy, C1-4haloalkoxy, cyano, nitro, amino, N-(C1-4alkyl) amino, N,N-di(C1-4alkyl)amino and N-(aryl-C1-4alkyl)amino; n is equal to integer 1, 2 or 3; R4 is selected from a group consisting of C3-6cycloalkyl, C3-6cycloalkyloxy and C3-6cycloalkylthio.

EFFECT: compounds of formula (I), having an apical sodium-dependent bile acid transporter (ASBT) and/or liver bile acid transporter (LBAT) inhibition activity.

13 cl, 8 tbl, 20 ex

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RU 2 838 460 C1

Authors

Gillberg Per-Goran

Starke Ingemar

Kulkarni Santosh S.

Dates

2025-04-16Published

2020-12-04Filed