METHOD FOR PRODUCTION OF JAK INHIBITORS AND THEIR INTERMEDIATE COMPOUNDS Russian patent published in 2022 - IPC C07D403/04 C07D471/04 C07D487/08 A61K31/437 A61P11/00 A61P37/06

Abstract RU 2786361 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the production of intermediate compounds for the production of drugs. A method for the production of a compound of the formula J-15 or its salt is proposed, where X is Br; PG¹ is a protective group for carboxylic acid; PG² is an amino protective group, and PG³ is an amino protective group. The method includes: (a) interaction of a compound of the formula J-14 or its salt with hydrazine to obtain the compound of the formula J-15, and (b) optionally, formation of salt of the compound J-15. Compounds of formulas J-14, J-15 and a method for the production of a compound of the formula J-16 are also proposed.

EFFECT: obtainment of intermediate compounds for JAK inhibitors.

20 cl, 3 tbl, 13 ex

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RU 2 786 361 C2

Authors

Colson, Pierre-Jean

Fass, Gene Timothy

Dates

2022-12-20—Published

2019-09-03—Filed