FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, namely to crystal hydrate of oxalate salt of 5-ethyl-2-fluor-4-(3-(5-(1-methylpyperidine-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]-pyridine-2-yl)-1H-indazole-6-yl)phenol. The invention also relates to a pharmaceutical composition based on the specified crystal hydrate of oxalate, a method for the treatment of inflammation associated with a respiratory disease or an eye disease, the use of the specified crystal hydrate of oxalate.
EFFECT: inhibitory activity relatively to JAK1, JAK2, JAK3, and Tyk2 enzymes with crystal hydrate of oxalate of 5-ethyl-2-fluor-4-(3-(5-(1-methylpyperidine-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]-pyridine-2-yl)-1H-indazole-6-yl)phenol, which is useful in the treatment of inflammation associated with respiratory and eye diseases.
20 cl, 8 dwg, 3 tbl, 7 ex
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