FIELD: medicine.
SUBSTANCE: invention relates to a method for producing (E)-2-(7-methoxy-1,3-benzodioxol-5-yl)-3-(4-methoxyphenyl)-prop-2-ene-nitrile (nitrile-stilbene - compound A- 104815), which consists in the fact that 4-methoxybenzaldehyde and 3-methoxy-(4,5-methylenedioxy)benzyl alcohol are used as the starting compound, which is chlorinated, then the halogen is replaced by the nitrile group, and the resulting derivative is fused with 4-methoxybenzaldehyde with the formation of compound A-104815.
EFFECT: development of a method for obtaining compound A-104815 with a high yield, which can be used in medicine for tumor chemotherapy.
1 cl, 10 dwg, 5 ex
A-104815
Title | Year | Author | Number |
---|---|---|---|
METHOD OF OBTAINING 4,5-DIARYLAZOLES | 2022 |
|
RU2799312C2 |
METHOD OF OBTAINING AMINOFURAZANS | 2018 |
|
RU2671414C1 |
METHOD FOR EXTRACTING LYMPHOTROPIN FROM INDUSTRIAL DYE "DISULPHINE BLUE" | 2021 |
|
RU2782930C2 |
SUBSTITUTED 4-ARYL-HEXAHYDRO-7H-IMIDAZOLO[1,5-B][1,2]OXAZINE-7-ONES AND METHOD FOR PRODUCTION THEREOF | 2018 |
|
RU2670097C1 |
PLATELET AGGREGATION INHIBITOR SHOWING ANTIMETASTATIC EFFECT | 2001 |
|
RU2192857C1 |
N,N'((ALKANDIYL)BIS[LABDA-7(9),13,14-TRIENE-4-CARBOXAMIDES] WITH ANTITUMOUR ACTIVITY | 2017 |
|
RU2654201C1 |
16α,17α-CYCLOHEXA-17β-2'-HYDROXYETHYL)-13β-METHYLGONA-1,3,5(10)-TRIEN-3-OL AND PREPARATION METHOD THEREOF | 2015 |
|
RU2601423C1 |
METHOD OF PRODUCING DYE ISOSULFAN BLUE (4-{[4-DIETHYLAMINO)PHENYL](2,5-DISULFOPHENYL)METHYLIDENE}-N,N-DIETHYLCYCLOHEXA-2,5-DIENE-1-IMINIUM) | 2023 |
|
RU2821634C1 |
GELATINE CAPSULE OF SELECTIVE VESSEL DESTRUCTION IN TUMOURS | 2015 |
|
RU2613146C1 |
PHOSPHORYL SUBSTITUTED 3-KETO-ANDROST-4-ENE-[16,17-D]PYRIDAZINES AND METHOD OF THEIR PREPARATION | 2023 |
|
RU2807870C1 |
Authors
Dates
2022-12-21—Published
2021-12-15—Filed