METHOD FOR OBTAINING NITRILO-STILBENE (COMPOUNDS A-104815) Russian patent published in 2022 - IPC C07D317/64 

Abstract RU 2786432 C2

FIELD: medicine.

SUBSTANCE: invention relates to a method for producing (E)-2-(7-methoxy-1,3-benzodioxol-5-yl)-3-(4-methoxyphenyl)-prop-2-ene-nitrile (nitrile-stilbene - compound A- 104815), which consists in the fact that 4-methoxybenzaldehyde and 3-methoxy-(4,5-methylenedioxy)benzyl alcohol are used as the starting compound, which is chlorinated, then the halogen is replaced by the nitrile group, and the resulting derivative is fused with 4-methoxybenzaldehyde with the formation of compound A-104815.

EFFECT: development of a method for obtaining compound A-104815 with a high yield, which can be used in medicine for tumor chemotherapy.

1 cl, 10 dwg, 5 ex

A-104815

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RU 2 786 432 C2

Authors

Kaprin Andrej Dmitrievich

Shegaj Petr Viktorovich

Bezborodova Olga Alekseevna

Plyutinskaya Anna Dmitrievna

Plotnikova Ekaterina Aleksandrovna

Khokhlova Varvara Andreevna

Blinnikov Aleksandr Nikolaevich

Semenov Viktor Vladimirovich

Semenova Marina Nikolaevna

Iskandarova Valentina Nikolaevna

Krylov Sergej Sergeevich

Sakharov Aleksej Mikhajlovich

Dates

2022-12-21Published

2021-12-15Filed