COMPOUND INHIBITING FORMATION OF C-MYC/MAX/DNA COMPLEX Russian patent published in 2020 - IPC C07D215/36 A61K31/47 

FIELD: chemistry.

SUBSTANCE: invention refers to compounds inhibiting formation of c-Myc/Max/DNA complex. Disclosed is a compound corresponding to structural formula 3a or 3b, where R_1a-R_1d each independently represent a hydrogen atom, halogen or C_1-6 alkoxy; R is C_1-4 alkyl, isoalkyl, cycloalkyl or phenyl; n is integer from 0 to 2; R_4a and R_4b each independently represent a hydrogen atom or C_1-4 alkyl; Ar is phenyl, 5–6-member heteroaryl or 8–12-member biheteroaryl, and heteroaryl contains at least one or more of N, S and O in a ring, and Ar can be unsubstituted or can be optionally substituted with one or more of the following substitutes: halogen, C_1-6 alkyl, C_1-6 alkylthio, C_1-6 haloalkyl, C_1-6 haloalkylthio, C_1-6 alkoxy, C_1-6 haloalkoxy, nitro group, cyano group, amino group, (C_1-6) alkoxy (C_1-6) alkylamino group, SF₅, S(O)CF₃, SCF₃, NHC(=O)CH₃, C(=O)NHCH₃, NHSO₂CH₃, pyrazole, ester or C_1-6 arylcarbonyl. Also presented is a composition containing said compound for treating or preventing bladder cancer.

3a 3b.

EFFECT: technical result is disclosed compounds have inhibitory effect on formation of complex c-Myc/Max/DNA with high selectivity.

4 cl, 6 tbl