FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, and it is mutant SPINK2 peptide, which inhibits protease activity of human HTRA1. The invention also relates to polynucleotide for use in the treatment or prevention of a disease related to HTRA1, containing a nucleotide sequence encoding an amino acid sequence contained in the obtained peptide, as well as to the use of such a peptide as part of vectors, conjugates, pharmaceutical compositions for use in the treatment or prevention of a disease related to HTRA.
EFFECT: invention allows for an increase in the efficiency of the treatment of diseases related to HTRA.
30 cl, 77 dwg, 2 tbl, 11 ex
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