FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, and it is mutant SPINK2 peptide, which inhibits protease activity of human HTRA1. The invention also relates to polynucleotide for use in the treatment or prevention of a disease related to HTRA1, containing a nucleotide sequence encoding an amino acid sequence contained in the obtained peptide, as well as to the use of such a peptide as part of vectors, conjugates, pharmaceutical compositions for use in the treatment or prevention of a disease related to HTRA.
EFFECT: invention allows for an increase in the efficiency of the treatment of diseases related to HTRA.
30 cl, 77 dwg, 2 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ANTIBODIES AGAINST HtrA1 AND METHODS OF THEIR APPLICATION | 2016 |
|
RU2750285C2 |
| THROMBOLYTICS FOR INTRAVASCULAR THROMBI | 2020 |
|
RU2822136C1 |
| METHODS FOR DETECTING FOLATE RECEPTOR 1 IN PATIENT SAMPLE | 2018 |
|
RU2759410C2 |
| ANTIBODY TO HUMAN CD73 | 2017 |
|
RU2754058C2 |
| NEW PROTEINS WITH INHIBITORY EFFECT RELATIVELY TO INSECTS | 2017 |
|
RU2781075C2 |
| ANTI-GARP ANTIBODY | 2016 |
|
RU2769379C2 |
| ANTI-ORAI1 ANTIBODY | 2015 |
|
RU2724742C2 |
| DNA ANTIBODY CONSTRUCTIONS FOR USE AGAINST LYME DISEASE | 2017 |
|
RU2813829C2 |
| ANTIBODY AGAINST SIRPα | 2019 |
|
RU2791002C2 |
| NOVEL PROTEINS HAVING INHIBITORY ACTIVITY ON INSECTS | 2015 |
|
RU2740313C2 |
