FIELD: medicine.
SUBSTANCE: invention relates to the field of medicine - oncohematology and can be used to predict the course of chronic lymphocytic leukemia. At the outpatient stage after diagnosis, the level of lymphocytes and the expression of PD-1 and LAG-3 on CD19+ cells in the blood are determined by flow cytometry. At the level of lymphocytes ≥ 67.11%, expression of PD-1 ≥ 40.81% and LAG-3 ≥ 24.62% on CD19+ cells, an unfavorable course of chronic lymphocytic leukemia is predicted.
EFFECT: application of the method makes it possible to predict the course of the disease already at the outpatient stage, in addition to the standard criteria for predicting the course of chronic lymphocytic leukemia.
1 cl, 2 ex, 1 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREDICTION OF RESPONSE TO ANTICANCER THERAPY IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA | 2023 |
|
RU2814269C1 |
| METHOD FOR DETECTION OF SURROGATE MARKERS OF MUTATIONS OF GENES OF VARIABLE REGIONS OF HEAVY CHAINS OF IMMUNOGLOBULINS IN CHRONIC LYMPHOCYTIC LEUKEMIA | 2023 |
|
RU2824086C1 |
| METHOD OF PREDICTING OVERALL SURVIVAL OF PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA AT STAGE A | 2014 |
|
RU2565453C1 |
| METHOD FOR PREDICTION OF OVERALL SURVIVAL OF MALE PATIENTS WITH CHRONIC LYMPHATIC LEUKEMIA IN STAGE A-C | 2020 |
|
RU2725877C1 |
| METHOD FOR PREDICTION OF OVERALL SURVIVAL OF PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA STAGE A-C IN DYNAMICS OF DISEASE | 2023 |
|
RU2821774C1 |
| METHOD FOR PREDICTING OVERALL SURVIVAL OF MALE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA IN STAGES A-C | 2022 |
|
RU2786963C1 |
| METHOD FOR PREDICTION CHEMOTHERAPEUTIC RESPONSE IN CHRONIC LYMPHATIC LEUKAEMIA | 2012 |
|
RU2495427C1 |
| METHOD OF SPECIFYING INDOLENT AND PROGRESSIVE FORMS OF STAGE A CHRONIC LYMPHOLEUKAEMIA | 2012 |
|
RU2490639C1 |
| METHOD FOR PREDICTING THE FLOW OF CHRONIC LYMPHOLEUKOSIS | 2004 |
|
RU2256921C1 |
| METHOD OF HORMONAL AND RADIATION PREPARATION OF PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKAEMIA FOR FOLLOWING CHEMOTHERAPY | 2013 |
|
RU2550663C2 |
