FIELD: biotechnology.
SUBSTANCE: invention relates to non-natural protein with zinc fingers, modulating expression of thioesterase gene of fatty acids B (FatB), where protein with zinc fingers contains six domains of zinc fingers in order from F1 to F6, wherein each zinc finger domain comprises a recognizing spiral area, and wherein the protein with zinc fingers comprises areas of recognition spirals. Invention also relates to a fused protein for modulating FatB gene expression, wherein the fused protein contains a zinc finger protein and a transcription regulation domain or a cleavage domain.
EFFECT: invention allows to produce plants and vegetal products with reduced content of unsaturated fatty acids.
17 cl, 20 dwg, 19 tbl, 15 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CONSTRUCTED PROTEINS WITH ZINC FINGERS DIRECTED TOWARDS GENES OF PLANTS INVOLVED IN BIOSYNTHESIS OF FATTY ACIDS | 2010 |
|
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| METHODS AND COMPOSITIONS FOR TREATING HUNTINGTON'S DISEASE | 2014 |
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| TARGETED MODIFICATION OF MALATE DEHYDROGENASE | 2013 |
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| CELL TARGETING MEDIATED BY CHIMERIC ANTIGEN RECEPTOR | 2018 |
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| RAPID TARGETING ANALYSIS IN CROPS FOR DETERMINING DONOR INSERTION | 2014 |
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RU2668819C2 |
| DNA DETECTION METHODS FOR SITE-SPECIFIC NUCLEASE ACTIVITY | 2013 |
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RU2678001C2 |
