PYRIMIDINE COMPOUND AND METHOD FOR ITS PRODUCTION Russian patent published in 2023 - IPC C07D401/02 C07D401/12 C07D401/14 C07D403/12 C07D403/14 A61K31/506 A61P1/16 A61P11/00 A61P13/12 A61P17/00 A61P19/02 A61P35/00 A61P37/00 A61P3/10 A61P25/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I), its tautomer or a pharmaceutically acceptable salt, which have autotaxin (ATC) inhibitory activity. In formula (I), Q is indanyl optionally substituted with m R¹ groups, m is an integer selected from 0-8, each of the m R¹ groups is independently selected from hydrogen or halogen; X is selected from -N=; Y is selected from -C(R²)=; Z is selected from -N(R³)-; L¹ is selected from L² is selected from L³ is selected from a single bond or R^a1 and R^a2 are each selected from hydrogen or C₁-C₃ alkyl; R^b1 and R^b2 are independently selected from hydrogen; is selected from a single bond, C4-C8 heterocycloalkyl, or a seven to eight membered N-spirocyclic group, wherein the C4-8 heterocycloalkyl and seven to eight membered N-spirocyclic group are optionally substituted with one R^c selected from halo or C₁-C₃ alkyl and 1 ring atom C₄-C₈ heterocycloalkyl is selected from N; n is an integer selected from 0-3; M¹, M² and M³ are independently selected from -N= or -N(R⁴)-; M⁴ is selected from C; M⁵ is selected from -C(R⁵)=; R² and R⁵ are each selected from hydrogen; R³ and R⁴ are each selected from hydrogen.

EFFECT: invention also relates to compounds of formulas I-1 and I-9 and a pharmaceutical composition containing an effective dose of a compound of formula (I) and having the property of autotaxin inhibition.

8 cl, 9 tbl, 19 ex