FIELD: chemistry.
SUBSTANCE: invention relates to the use of 9-benzoyl-8-hydroxy-6-(2-hydroxy-5-chlorophenyl)-2-phenyl-1-thia-3,6-diazaspiro[4.4]nona-2,8-diene-4,7-dione (1) as an antifungal agent against Cryptococcus neoformans.
EFFECT: pronounced antifungal activity against Cryptococcus neoformans in the absence of cytotoxic and hemolytic action, provided by an agent based on 9-benzoyl-8-hydroxy-6-(2-hydroxy-5-chlorophenyl)-2-phenyl-1-thia-3,6- diazaspiro[4.4]nona-2,8-diene-4,7-dione.
1 cl, 2 tbl, 3 ex
| Title |
Year |
Author |
Number |
| USE OF 9-BENZOYL-8-HYDROXY-6-(2-HYDROXYETHYL)-2-PHENYL-1-THIA-3,6-DIAZASPIRO[4.4]NONE-2,8-DIEN-4,7-DIONE AS AN ANTIFUNGAL DRUG |
2022 |
- Maslivets Andrei Nikolaevich
- Tretiakov Nikita Alekseevich
- Balandina Svetlana Iurevna
|
RU2791043C1 |
| METHOD FOR PREPARATION OF 9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-2-PHENYL-1-THIA-3,6-DIAZASPIRO[4,4]NON-2,8-DIENE-4,7-DIONES |
2016 |
- Stepanova Ekaterina Evgenevna
- Maslivets Andrej Nikolaevich
- Kobelev Aleksandr Ivanovich
- Balandina Svetlana Yurevna
|
RU2631432C1 |
| APPLICATION OF 8-HYDROXY-6-(2-HYDROXYETHYL)-9-(4-METHYLBENZOYL)-2-PHENYL-1-THIA-3,6-DIAZASPIRO[4.4]NON-2,8-DIENE-4,7-DIONE AS AN AGENT WITH ANTIMICROBIAL ACTIVITY AGAINST THE S. AUREUS CULTURE |
2023 |
- Tretiakov Nikita Alekseevich
- Maslivets Andrei Nikolaevich
- Balandina Svetlana Iurevna
|
RU2803888C1 |
| METHOD OF PRODUCING 2-AMINO-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-1-THIA-3,6-DIAZASPIRO[4.4]NONA-2,8-DIENE-4,7-DIONE |
2019 |
- Maslivets Andrej Nikolaevich
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- Stepanova Ekaterina Evgenevna
- Balandina Svetlana Yurevna
|
RU2707195C1 |
| (Z)-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-2-(((Z)-2-OXOINDOLIN-3-YLIDENE)HYDRAZONO)-1-THIA-3,6-DIAZASPIRO[4.4 ]NON-8-EN-4,7-DIONES WITH ANTIMICROBIAL ACTIVITY |
2021 |
- Mashevskaya Irina Vladimirovna
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- Balandina Svetlana Yurevna
- Lukmanova Dzhamilya Nailevna
|
RU2763739C1 |
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2022 |
- Maslivets Andrei Nikolaevich
- Tretiakov Nikita Alekseevich
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|
RU2790479C1 |
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2021 |
- Salimova Elena Viktorovna
- Savchenko Rimma Gafurovna
- Parfenova Lyudmila Vyacheslavovna
|
RU2780014C1 |
| ANTITUBERCULOSIS AGENT BASED ON (Z)-9-AROYL-8-HYDROXY-6-(2-HYDROXYPHENYL)-2-(((E)-PYRIDIN-3-YLMETHYLENE)HYDRAZONO)-1-THIA-3,6-DIAZOSPIRO[4.4]NON-8-ENE-4,7-DIONES |
2023 |
- Lukmanova Dzhamilia Nailevna
- Mashevskaia Irina Vladimirovna
- Balandina Svetlana Iurevna
|
RU2808987C1 |
| APPLICATION OF 2-[(R-BENZYLIDENE)HYDRAZONO]-8-HYDROXY-6-(2-HYDROXYPHENYL)-9-AROYL-1-THIA-3,6-DIAZASPIRO[4.4]NONA-8-EN-4,7-DIONES AS AGENTS WITH ANTI-INFLAMMATORY ACTIVITY |
2022 |
- Mashevskaia Irina Vladimirovna
- Lukmanova Dzhamilia Nailevna
- Apushkin Danila Iurevich
- Utushkina Taisiia Andreevna
- Iakushina Karolina Evgenevna
- Andreev Aleksandr Igorevich
|
RU2783241C1 |
| (2Z)-2-[(3Β, 4Α, 8Α, 11Α, 14Β, 16Β)-16-(ACETYLOXY)-3-({3-[(4-AMINOBUTYL)AMINO]PROPYL}AMINO)-11-HYDROXY-4,8,10,14-TETRAMETHYL GONANE-17-YLIDENE]-6-METHYLHEPT-5-ENOIC ACID WITH ANTIMICROBIAL AND FUNGICIDAL ACTIVITY AND METHOD FOR PRODUCTION THEREOF |
2019 |
- Salimova Elena Viktorovna
- Tretyakova Elena Valerevna
- Parfenova Lyudmila Vyacheslavovna
|
RU2730604C1 |
